Document detail
ID

oai:HAL:hal-04106373v1

Topic
anti-infective agents antibacterials antifungals antivirals French national health data system... pregnancy [SDV.SP.PHARMA]Life Sciences [q-bi... [SDV.MHEP.GEO]Life Sciences [q-bio... [SDV.SPEE]Life Sciences [q-bio]/Sa...
Author
Tubiana, Sarah Simha Sibiude, Jeanne Herlemont, Philippe Drouin, Jérôme Picone, Olivier Duval, Xavier Weill, Alain Zureik, Mahmoud Dray-Spira, Rosemary
Langue
en
Editor

HAL CCSD;Wiley

Category

sciences: life sciences

Year

2023

listing date

12/15/2023

Keywords
using 4% [sdv french 0 sciences prescribed 2% influenza health data 7% nationwide aapc anti-infective pregnancy 2010
Metrics

Abstract

International audience; Aims: To describe the trends in anti-infective use during pregnancy between 2010 and 2019 and determine whether they were prescribed according to drug foetal safety international classification systems.Methods: We conducted a population-based, nationwide study using the French national health data system including all pregnancies ended between 2010 and 2019.

Anti-infective agents were considered according to their pharmacological group and potential harmful risk using the Australian and Swedish classification systems.

Prevalence rate was estimated annually and by trimester.

Average annual percent change (AAPC) and 95% confidence intervals (CIs) were calculated using Joinpoint regression.Results: Among 7 571 035 pregnancies, 3 027 031 (40.0%) received ≥1 antibacterial.

This proportion decreased significantly from 41.5% in 2010 to 36.1% in 2019 (AAPC = −1.7%, [95%CI, −2.5 to −1.0%]).

Conversely, use of antiviral agents increased during the 10-year study period for anti-herpes simplex virus agents (AAPC = 4.4%, [3.7–5.2%]), influenza agents (AAPC = 25.4%, [6.2–48.1%]) and for HIV-antiretroviral agents (AAPC = 1.3%, [0.6–2.0%]).

Use of influenza vaccine increased from 0.2% in 2010 to 4.2% in 2019 (AAPC = 49.7%, [39.3–60.9%]).

Among all pregnancies, 0.9% had been exposed to a potentially harmful anti-infective agent increasing from 0.7% in 2010 to 1.2% in 2019 (AAPC = 6.4%, [4.4–8.5%]).

Conclusion: Based on >7 million pregnancies identified from French nationwide data, this study showed that antibacterials are frequently prescribed during pregnancy although their use has decreased over the past 10 years.

Our results suggest that anti-infective agents are generally prescribed in accordance with recommendations, although with a potential for improvement in influenza vaccination.

Tubiana, Sarah Simha,Sibiude, Jeanne,Herlemont, Philippe,Drouin, Jérôme,Picone, Olivier,Duval, Xavier,Weill, Alain,Zureik, Mahmoud,Dray-Spira, Rosemary, 2023, Trends in anti-infective use during pregnancy in France between 2010 and 2019: a nationwide population-based study, HAL CCSD;Wiley

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